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TRELSTAR is a type of prescription drug known as a LHRH agonist, used for the treatment
of advanced prostate cancer.
Prostate cancer is the most common cancer in men in the U.S., excluding skin cancer
and is the second leading cause of death due to cancer in men.
Men with prostate cancer have the option of several types of treatment including:
watchful waiting, surgery, radiation therapy, cryotherapy, chemotherapy and hormonal
treatment. The goal of hormone therapy is to keep cancer cells from getting the
male hormones they need to grow. As a LHRH agonist TRELSTAR works to achieve this
goal.
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Prostate Cancer Foundation, FAQs About Prostate Cancer, How Common is Prostate Cancer?,
http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.189965/k.743F/FAQs_About_Prostate_Cancer.htm#common
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American Cancer Society, Cancer Facts & Figures 2008, pg. 19, http://www.cancer.org/downloads/STT/2008CAFFfinalsecured.pdf
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International Urology Network, Inside Urology News, August 2005, pg. 1, https://www.iun-online.com/content/iun/publications/insideurology/aug_2005.pdf
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Prostate Cancer Foundation, About Prostate Cancer, How Common is Prostate Cancer?,
http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.4983495/k.5C76/About_Prostate_Cancer.htm
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Prostate Cancer Foundation, About the Prostate, Normal Anatomy, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.68230/k.DAE7/What_Is_the_Prostate.htm
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Prostate Cancer Foundation, Risk Factors, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.70619/k.446E/Risk_Factors.htm
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American Cancer Society, Cancer Facts & Figures 2008, pg. 19, http://www.cancer.org/downloads/STT/2008CAFFfinalsecured.pdf
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American Cancer Society, Cancer Facts & Figures 2008, pg. 17, http://www.cancer.org/downloads/STT/2008CAFFfinalsecured.pdf
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Prostate Cancer Foundation, Risk Factors, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.70619/k.446E/Risk_Factors.htm
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Prostate Cancer Foundation, Risk Factors, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.70619/k.446E/Risk_Factors.htm
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Prostate Cancer Foundation, Non-Risk Factors, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.70620/k.B40A/NonRisk_Factors.htm
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American Cancer Society, Cancer Facts & Figures 2008, pg. 19, http://www.cancer.org/downloads/STT/2008CAFFfinalsecured.pdf
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American Cancer Society, Cancer Facts & Figures 2008, pg. 17, http://www.cancer.org/downloads/STT/2008CAFFfinalsecured.pdf
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American Cancer Society, Cancer Facts & Figures 2008, pg. 17, http://www.cancer.org/downloads/STT/2008CAFFfinalsecured.pdf
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Prostate Cancer Foundation, FAQs About Prostate Cancer, How Common is Prostate Cancer?
http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.189965/k.743F/FAQs_About_Prostate_Cancer.htm#curable
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American Cancer Society, Cancer Facts & Figures 2008, Risk Factors, http://www.cancer.org/downloads/STT/2008CAFFfinalsecured.pdf
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National Prostate Cancer Coalition, Risk Factors, http://www.zerocancer.org/site/PageServer?pagename=APC_Risk_Factors
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Prostate Cancer Foundation, About Prostate Cancer, How Curable is Prostate Cancer,
http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/%0D%0Ab.4983495/k.5C76/About_Prostate_Cancer.htm
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Prostate Cancer Foundation, Risk Factors, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.70619/k.446E/Risk_Factors.htm
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Prostate Cancer Foundation, Obesity and Prostate Cancer, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.4051625/k.8967/Obesity_and_Prostate_Cancer.htm
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Prostate Cancer Foundation, Dietary Fats and Red Meat, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.788359/k.6989/Dietary_Fats_and_Red_Meat.htm
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Prostate Cancer Foundation, FAQs About Prostate Cancer, If there are no symptoms,
how is PC detected?, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.189965/k.743F/FAQs_About_Prostate_Cancer.htm
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National Cancer Institute, Early Prostate Cancer, http://www.cancer.gov/cancertopics/factsheet/Detection/early-prostate
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Core Oncology Web site, General Cancer Facts, http://www.coreoncology.com/patient/statistics.aspx
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American Cancer Society, Cancer Facts & Figures 2008, Risk Factors, http://www.cancer.org/downloads/STT/2008CAFFfinalsecured.pdf
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Prostate Cancer Foundation, FAQs About Prostate Cancer, How Curable is Prostate
Cancer?, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.189965/k.743F/FAQs_About_Prostate_Cancer.htm
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American Cancer Society, Prostate Cancer Survival Rates, http://www.cancer.org/docroot/CRI/content/CRI_2_2_6x_Prostate_Cancer_Survival_Rates.asp
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Centers for Disease Control, 2003 National Hospital Discharge Survey, http://www.cdc.gov/nchs/data/ad/ad359.pdf
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Prostate Cancer Foundation, About the PCF, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.4980403/k.DE87/About_PCF.htm
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Prostate Cancer Foundation, FAQs About Prostate Cancer, http://www.prostatecancerfoundation.org/site/c.itIWK2OSG/b.189965/k.743F/FAQs_About_Prostate_Cancer.htm
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http://www.dictionary.com
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Atlas of Human Anatomy, Frank H. Netter, MD, Ciba-Geigy Corporation, Summit, NJ,
1989.
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Indications and Usage
TRELSTAR® Depot and TRELSTAR® LA are indicated in
the palliative treatment of advanced prostate cancer. TRELSTAR Depot and TRELSTAR
LA offer an alternative treatment for prostate cancer when orchiectomy or estrogen
administration are either not indicated or unacceptable to the patient.
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Safety Information
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After your first injection of TRELSTAR, you might feel a temporary increase in your
cancer symptoms, such as pain in your bones. This is because the amount of testosterone
in your bloodstream actually goes up for a short period after the injection. If
your symptoms increase later than the first week or two following an injection,
tell your doctor. The most common side effects that patients taking TRELSTAR have
are actually the effect of lowering testosterone levels. The most common effect
of lowering testosterone is hot flushes or flashes. These are like the hot flashes
women have around the time of menopause. Other side effects include bone pain, impotence
(sexual side effect), headache, leg pain, and swelling in the legs. Women who are
or may become pregnant and those who are allergic to this type of drug should not
take TRELSTAR. For more information on these and other side effects, please talk
to your doctor.
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References
References